I recently put a question out to the internet on what needs to be done if you upgrade a server that acts as a DFS namespace server and is pointed to by several DFS folders.

If the new server has a new name, you will need to remove the old server as a Namespace Server for each domain-based DFS namespace it is a member of. In addition, you will have to remove and re-point each folder target to the new path.

In my scenario we were doing an in-place upgrade and the server would keep the same name. But since the upgrade results in the machine having a new SID in AD there is some work that needs to be done. I found in this situation you only need to remove the server as a Namespace Server and re-add it once the new server is in place so the new SID is used in AD's DFS configuration. All the DFS folder targets can be left alone as SID is not used here, just the path.

We are not using DFS-R on these folders, but I believe if you were, you would need to redo the replication partners as DFS-R relies on the SID information stored in Active Directory.